Blar i forfatter "Joshi, Dhira"

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    • Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins 

      Wirth, Martina; Zhang, Wenxin; Razi, Minoo; Nyoni, Lynet; Joshi, Dhira; O'Reilly, Nicola; Johansen, Terje; Tooze, Sharon; Mouilleron, Stephane (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
      Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3-interacting region (LIR) motif. LIR motifs can be highly selective for ATG8 subfamily proteins (LC3s/GABARAPs), however the molecular determinants regulating ...

    • Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity 

      Wirth, Martina; Mouilleron, Stephane; Zhang, Wenxin; Abudu, Yakubu Princely; Jain, Ashish; Olsvik, Hallvard Lauritz; Bruun, Jack-Ansgar; Razi, Minoo; Jefferies, Harold B.J.; Lee, Rebecca; Joshi, Dhira; O'Reilly, Nicola; Johansen, Terje; Tooze, Sharon A (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      <p>Autophagy is a highly conserved degradative pathway, essential for cellular homeostasis and implicated in diseases including cancer and neurodegeneration. Autophagy-related 8 (ATG8) proteins play a central role in autophagosome formation and selective delivery of cytoplasmic cargo to lysosomes by recruiting autophagy adaptors and receptors. The LC3-interacting region (LIR) docking site (LDS) of ...